Comparative trial of 2 weeks and 8 weeks cyclophosphamide in steroid-sensitive relapsing nephrotic syndrome of childhood
نویسندگان
چکیده
منابع مشابه
Treatment of children with frequently relapsing steroid-sensitive nephrotic syndrome: recent trial results
2014 Despite being an orphan disease idiopathic nephrotic syndrome in children is the most frequent glomerular disease in this age group. A total of 80–90% of children between 2 and 10 years of age respond to corticosteroids, but carry the risk of relapses that may even appear frequently (frequently relapsing nephrotic syndrome, [FRNS]). To avoid repeated courses of corticosteroids and associat...
متن کاملLong-term effects of cyclophosphamide therapy in steroid-dependent or frequently relapsing idiopathic nephrotic syndrome.
BACKGROUND It has been demonstrated that alkylating agents such as cyclophosphamide (CYP) are effective in reducing the risk of relapse in frequently relapsing (FRNS) and steroid-dependent nephrotic syndrome (SDNS). Little is known about prognostic factors in SDNS and FRNS treated by CYP. The objectives of this study are to determine long-term outcomes and factors associated with sustained remi...
متن کاملsteroid-responsive nephrotic syndrome of childhood
Cyclophosphamide has been shown to be effective in preventing relapse of steroid-responsive nephrotic syndrome of childhood (Barratt and Soothill, 1970). However, a similar significant effect was not observed by Abramowicz et al. (1970), in a doubleblind trial of azathioprine. This drug was administered in a dosage of 60 mg/M2 surface area per day for 6 months to steroid-responsive nephrotic ch...
متن کاملSteroid Sensitive Nephrotic Syndrome in Children
Nephrotic Syndrome (NS) is one of the most frequent glomerular diseases seen in children. Children who go into complete remissin following treatment with corticosteroids are classified as having “steroid sensitive” NS. In developed countries over 80% of children with idiopathic NS have steroid sensitive disease although response to steroids is somewhat tempered in developing countries, especial...
متن کاملDisease course in steroid sensitive nephrotic syndrome.
OBJECTIVE To review the disease course in patients with steroid sensitive nephrotic syndrome (SSNS) and the factors that determine outcome DESIGN Retrospective, analytical SETTING Pediatric Nephrology Clinic at referral center in North India PARTICIPANTS/PATIENTS All patients with SSNS evaluated between 1990 and 2005 INTERVENTION: None MAIN OUTCOME MEASURES Disease course, in patients w...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1973
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.48.4.286